Anti-HIV drugs kill the immune system

Anti-retroviral drugs are toxic in a number of ways, see The Case against HIV, section 5.3.

The specific reported toxicities include the killing of T-cells (section 5.3.3.14), which is supposed to be what “HIV” does. A new addition to this section is the report that integrase inhibitors also contribute to loss of T-cells:

R. Prasad, “IISc: HIV drug elvitegravir lowers the efficiency of immune system”, Hindu Times, 16 December

The research article is Nishana et al., “HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination”, Cell Death & Disease, 8 (2017) :e2852. doi: 10.1038/cddis.2017.237; it is open access.

Abstract (PMID: 28569776)
Integrase inhibitors are a class of antiretroviral drugs used for the treatment of AIDS that target HIV integrase, an enzyme responsible for integration of viral cDNA into host genome. RAG1, a critical enzyme involved in V(D)J recombination exhibits structural similarity to HIV integrase. We find that two integrase inhibitors, Raltegravir and Elvitegravir, interfered with the physiological functions of RAGs such as binding, cleavage and hairpin formation at the recombination signal sequence (RSS), though the effect of Raltegravir was limited. Circular dichroism studies demonstrated a distinct change in the secondary structure of RAG1 central domain (RAG1 shares DDE motif amino acids with integrases), and when incubated with Elvitegravir, an equilibrium dissociation constant (Kd) of 32.53±2.9 μM was determined by Biolayer interferometry, leading to inhibition of its binding to DNA. Besides, using extrachromosomal assays, we show that Elvitegravir inhibited both coding and signal joint formation in pre-B cells. Importantly, treatment with Elvitegravir resulted in significant reduction of mature B lymphocytes in 70% of mice studied. Thus, our study suggests a potential risk associated with the use of Elvitegravir as an antiretroviral drug, considering the evolutionary and structural similarities between HIV integrase and RAGs.

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This is just one illustration of the much-neglected fact that prescription drugs, so often advertised as “specific” to treatment of a disease, may do all sorts of other things as well. Chemicals, molecules, simply do what corresponds to their chemical structure, they don’t discriminate according to what we would like them to do. There are no “side” effects, there are just effects, even though the pharmaceutical industry tries to obfuscate that. Millions of people are being fed statins, for example, to lower their blood-cholesterol levels without being told that statins also interfere with coenzyme Q10 which the body makes and uses in all energy-related reactions; which is why a “side” effect of statins is muscle weakness.

 

AIDS and Cold-War disinformation

A German periodical, Zeitschrift für Anomalistik, has a review of a book (ftdetrick-zfa) about the possible involvement of the East German Stasi (Security Service) in the disinformation campaign disseminating the Fort Detrick conspiracy theory — that HIV was created in biological warfare experiments in the USA.

The book was published in 2014. A year earlier, a lengthy article on the same topic had been published in Politics and the Life Sciences (32 #2, 2-99): “Disinformation squared: Was the HIV-from-Fort-Detrick myth a Stasi success?”, by Erhard Geissler and Robert Hunt Sprinkle ().

It is taken for granted that HIV is the cause of AIDS.

 

 

HIV infectivity: high, low, or non-existent?

Analysis of essentially all published results of HIV tests in the USA reveals properties unlike those of an infectious agent (The Origin, Persistence and Failings of HIV/AIDS Theory, McFarland 2007).  In every social sector, the same regularities are seen: rates of testing positive vary by US official “racial” and ethnic classification (black >> native American > Caucasian > Asian); rates of testing positive decrease drastically from birth into the teens and increase from the late teens into middle age and then decline again; in early teens, females are more likely to be HIV+ than are males but by the 20s that is reversed (see references cited in section 3.3.5 in The Case against HIV).

In cloned HIV virions, only between 1 in 10,000 and 1 in 10 million were infectious (Layne et al., “Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus”, Virology, 189 (1992) 695-714).

The instructions that come with HIV test kits warn that a positive test is not proof of infection.

Innumerable conditions produce HIV+ results (see references cited in section 3.2 in The Case against HIV), so all claims to have measured infectivity or transmission are at best dubious and at worst — or more accurately — meaningless. There is no valid published evidence of transmission or infectivity (see references cited in section 3.3 in The Case against HIV). The Office of Medical and Scientific Justice successfully defended more than 50 individuals http://www.omsj.org/human-rights/52nd charged with transmitting HIV because the prosecution could not prove HIV to be transmissible.

Researching phantoms

It can take a long time before researchers realize that they have been on a wild-goose chase, pursuing phantoms (“Phantom phantoms”, pp. 110-116 in Fatal Attractions: The Troubles with Science, Paraview Press 2001); even “an unknown phenomenon [that] towered 6 standard deviations above the mundane background of known physics — enough to satisfy a 99.9999% confidence level that it wasn’t a fluke” and that had been reported in more than a dozen experiments turned out to be non-existent.

Given that HIV/AIDS theory is wrong (The Case against HIV), observations and experiments and clinical trials will continually throw up what seem to be conundrums, which serve as the basis for yet more research. To date, mainstream HIV/AIDS researchers have failed to recognize the accumulation of conundrums and absurdities  as being in reality the hard evidence that HIV/AIDS theory is simply wrong: HIV is not infectious, and “HIV” doesn’t cause AIDS.

Mainstream science sticks to theories that had once been accepted by ignoring anomalies, conundrums, absurdities for as long as possible (Thomas S. Kuhn, The Structure of Scientific Revolutions, University of Chicago Press 1970 [2nd ed., enlarged; 1st ed. was 1962]). Things that don’t fit an existing theory are accommodated by ad hoc adjustments (Imre Lakatos, “History of science and its rational reconstruction”, pp. 1-40 in Method and Appraisal in the Physical Sciences, ed. Colin Howson, Cambridge University Press 1976), just as Ptolemy long maintained belief in the circular perfection of heavenly motions by adding epicycles upon epicycles, wheels within wheels, to avoid acknowledging that the movements are not really circular after all.

So too HIV/AIDS researchers create new hypotheses to bolster their belief whenever they seem unable to explain what they observe. Since all the data point to HIV not being infective, or being apparently infective to so low a degree as to be incapable of producing an epidemic, auxiliary hypotheses were suggested which have become accepted as shibboleths:

1. The epidemic in Africa is said to have come about because of an incredible rate of promiscuity. Sexually active South Africans (black South Africans, that is) are postulated to have an average of 10 sexual partners at any give time and to change them about annually (pp. 63-65 in James Chin, The AIDS Pandemic, Radcliffe 2007).
2. Soon after initial infection, there is an “acute phase” where large amounts of HIV are present, and intercourse during that phase makes transmission much more likely: infectivity is very high during these short periods, so overall measurements of transmissibility are deceiving.

The first suggestion is absurd, since such behavior would be so visibly evident that it could not be overlooked; yet it is not observed.

The second suggestion has been undermined by a careful re-analysis of the single study on which it had been based: the “excess hazard-months attributable to the acute phase of infection” is about 5.3, not the previously estimated 31-to-141 (Bellan et al., “Reassessment of HIV-1 acute phase infectivity: accounting for heterogeneity and study design with simulated cohorts”, PLoS Medicine, 12(3):  e1001801).

HIV/AIDS research is chasing red herrings, phantoms, in a decades-long wild-goose change that has been enormously expensive in lives and in dollars. But the interests vested in this state of affairs — drug-company profits, research careers, administrative careers, honors and awards — are so widespread and powerful that the actual evidence is given little or no chance of speaking for itself. Try to imagine what it would take for Anthony Fauci to shed cognitive dissonance and admit that he has been so disastrously wrong.

 

About money, and HIV in Estonia

A correspondent from Estonia shared this recent news:

“Unique HIV is spreading in Estonia
Research has shown that recombined (?) [recombinant = hybrids of the known “strains”] form of HIV spreads in Estonia. People get infected locally and it is not brought in from abroad.
‘We have done more than 10 years of research and we do not have exporters [?importers?] of HIV, we do not get it from Russia or Western Europe’, says Irja Lutsar, professor of medical microbiology and virology. She added that people get infected with HIV locally and a recombined [recombinant] form of HIV is spreading here.
‘Our virus is unique but if you ask where it came from then I do not know answer to that.’”

Professor Lutsar might find some clues in de Harven’s article in Journal of the American Physicians and Surgeons  as well as in The Case against HIV.

“Also, US, British and Finnish embassies here recently wrote a public letter to Estonian parliament about HIV”.

Part of that letter reads;
“The U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) is the largest commitment by any nation to combat a single disease. Through PEPFAR, the U.S. government works with vulnerable, developing nations on a framework to combat HIV/AIDS. Since 2009, the U.S. government has committed nearly $65 billion to support PEPFAR and its global HIV/AIDS response. While gains have been real, progress against this disease, even in the United States, has been uneven.”

That inevitably brought to mind the quote attributed to the late Republican fiscal conservative, Senator Everett Dirksen:

“A billion here, a billion there, pretty soon, you’re talking real money”.

(As commonly with the most delightful quotes, this may be a mis-attribution)

At any rate, the United States has apparently disbursed $65 billion without anyone getting any benefit and some undoubtedly being harmed as a result of being fed toxic drugs while not only healthy but even HIV-negative.
I shouldn’t have said, of course, that no one benefited. The drug companies and their shareholders and executives have certainly benefited.

 

HIV/AIDS history and facts

Cardiac surgeon  Donald W. Miller has written a wonderfully comprehensive yet concise analysis of the genesis of HIV/AIDS and of the actual facts:

“HIV/AIDS: Unmasking Medical Falsehood…”. 
https://www.lewrockwell.com/2015/08/donald-w-miller-jr-md/unmasking-medical-falsehood/

It illustrates the feeling of alienation, of being relatively sane in an insane world, that I get periodically:

Who looks at evidence? Almost no one
http://wp.me/p2VG42-5L