HIV/AIDS Skepticism

Pointing to evidence that HIV is not the necessary and sufficient cause of AIDS

Archive for the ‘clinical trials’ Category

Larry Kramer in Love and Anger

Posted by Henry Bauer on 2017/01/30

Larry Kramer in Love and Anger is a 2015 HBO documentary. It recounts most of the history of AIDS through Kramer’s personal involvement and it is largely accurate in what it discusses, though omitting and ignoring some crucial points.

Watching it brought home to me once again what an enormous tragedy this has been and still is and will continue to be because the ultimate crux remains unaccepted: namely, that “science” including medical science can go wrong, and that there are no systemic safeguards against that, no checks or balances, because minority voices within the scientific community are not attended to, instead are castigated and persecuted.

This film gives a good account of the fear that spread among gay men as a mysterious syndrome of illnesses was bringing deaths, several hundred thousand in about half-a-dozen years. But the film also misses the opportunity to make the case against HIV, despite some significant clues. Thus Kramer’s 1978 novel, Faggots, is correctly described as his jeremiad against the fast-lane lifestyle that included much health-damaging use of “recreational” drugs. The film might well have been pointed out that this preceded the appearance of AIDS and could indeed explain why so many people became very ill — as some of them recognized, for instance Michael Callen and his physician Sonnabend. Again, Kaposi’s sarcoma (KS) is mentioned as a characteristic AIDS disease, but the film neglects to point out that KS virtually dropped out of the picture after some years as insightful gay men abandoned the use of the nitrite inhalants (“poppers”) that cause this damage to blood vessels (“AIDS KS” is probably different from the classic KS.)

Completely missing is the tragic story of how HIV came to be the accepted cause of AIDS, essentially by declaration at a press conference before any scientific publication.

Kramer’s initiatives are properly credited for revision of the FDA’s procedures for approving drugs — but missing is a discussion of the damaging consequences, not only because of the toxicity of AZT and later “anti-retroviral” drugs but because the fast-track approval system is now abused routinely by Big Pharma to bring to market avalanches of new drugs that reveal their toxicity within a short time after marketing: note the TV and print announcements by lawyers about class-action suits against such medications as Pradaxa, Xeralto, Invokana, and others at the very same time as the drug companies continue to advertise those drugs with dishonest descriptions of potential benefits (“remission is possible”, for example) and down-playing of “side” effects, for instance in TV ads showing healthy actors instead of actual patients actually on the drugs.

The film applauds the introduction of protease inhibitors, but fails to describe their toxicities, again despite obvious clues. Thus the film opens and closes with Kramer in hospital after a liver transplant; and there is a short clip of Kramer warning earlier about the side effects of his medications. The New York Times review of the film of course says, misleadingly, “liver transplant necessitated by his H.I.V. infection” instead of “made necessary by the anti-retroviral medication including protease inhibitors”: “Drug-induced hepatitis and hepatic decompensation (and rare cases of fatalities) have been reported with all PIs” (Table 14, Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents, 8/8/2014).

And of course nothing is said about dissent from HIV/AIDS theory.

So this documentary can serve only as a reminder of the tragic history of AIDS. I realized also how the nature of the tragedy has changed. Initially it was the mis-identification of the cause as HIV and the subsequent hundreds of thousands of deaths from AZT. But nowadays this has been compounded by the abuse of HIV tests as proof of infection, whereby no sector of society is free from the danger of mis-diagnosis and subsequent mistreatment. Since pregnancy seems to stimulate positive “HIV” tests, especially with women of African ancestry, women and their fetuses and babies are being harmed in significant numbers and will continue to be until the HIV/AIDS blunder is corrected.

For the facts about HIV and AIDS, see The Case against HIV. For why HIV cannot be the cause of AIDS, and the story of how the error was made and entrenched, read The Origin, Persistence and Failings of HIV/AIDS Theory [Jefferson (NC): McFarland 2007].

Posted in antiretroviral drugs, clinical trials, HIV does not cause AIDS, HIV risk groups, HIV tests, HIV/AIDS numbers, uncritical media | Tagged: , | 1 Comment »

HIV infectivity: high, low, or non-existent?

Posted by Henry Bauer on 2016/07/31

Analysis of essentially all published results of HIV tests in the USA reveals properties unlike those of an infectious agent (The Origin, Persistence and Failings of HIV/AIDS Theory, McFarland 2007).  In every social sector, the same regularities are seen: rates of testing positive vary by US official “racial” and ethnic classification (black >> native American > Caucasian > Asian); rates of testing positive decrease drastically from birth into the teens and increase from the late teens into middle age and then decline again; in early teens, females are more likely to be HIV+ than are males but by the 20s that is reversed (see references cited in section 3.3.5 in The Case against HIV).

In cloned HIV virions, only between 1 in 10,000 and 1 in 10 million were infectious (Layne et al., “Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus”, Virology, 189 (1992) 695-714).

The instructions that come with HIV test kits warn that a positive test is not proof of infection.

Innumerable conditions produce HIV+ results (see references cited in section 3.2 in The Case against HIV), so all claims to have measured infectivity or transmission are at best dubious and at worst — or more accurately — meaningless. There is no valid published evidence of transmission or infectivity (see references cited in section 3.3 in The Case against HIV). The Office of Medical and Scientific Justice successfully defended more than 50 individuals http://www.omsj.org/human-rights/52nd charged with transmitting HIV because the prosecution could not prove HIV to be transmissible.

Researching phantoms

It can take a long time before researchers realize that they have been on a wild-goose chase, pursuing phantoms (“Phantom phantoms”, pp. 110-116 in Fatal Attractions: The Troubles with Science, Paraview Press 2001); even “an unknown phenomenon [that] towered 6 standard deviations above the mundane background of known physics — enough to satisfy a 99.9999% confidence level that it wasn’t a fluke” and that had been reported in more than a dozen experiments turned out to be non-existent.

Given that HIV/AIDS theory is wrong (The Case against HIV), observations and experiments and clinical trials will continually throw up what seem to be conundrums, which serve as the basis for yet more research. To date, mainstream HIV/AIDS researchers have failed to recognize the accumulation of conundrums and absurdities  as being in reality the hard evidence that HIV/AIDS theory is simply wrong: HIV is not infectious, and “HIV” doesn’t cause AIDS.

Mainstream science sticks to theories that had once been accepted by ignoring anomalies, conundrums, absurdities for as long as possible (Thomas S. Kuhn, The Structure of Scientific Revolutions, University of Chicago Press 1970 [2nd ed., enlarged; 1st ed. was 1962]). Things that don’t fit an existing theory are accommodated by ad hoc adjustments (Imre Lakatos, “History of science and its rational reconstruction”, pp. 1-40 in Method and Appraisal in the Physical Sciences, ed. Colin Howson, Cambridge University Press 1976), just as Ptolemy long maintained belief in the circular perfection of heavenly motions by adding epicycles upon epicycles, wheels within wheels, to avoid acknowledging that the movements are not really circular after all.

So too HIV/AIDS researchers create new hypotheses to bolster their belief whenever they seem unable to explain what they observe. Since all the data point to HIV not being infective, or being apparently infective to so low a degree as to be incapable of producing an epidemic, auxiliary hypotheses were suggested which have become accepted as shibboleths:

  1. The epidemic in Africa is said to have come about because of an incredible rate of promiscuity. Sexually active South Africans (black South Africans, that is) are postulated to have an average of 10 sexual partners at any give time and to change them about annually (pp. 63-65 in James Chin, The AIDS Pandemic, Radcliffe 2007).
  2. Soon after initial infection, there is an “acute phase” where large amounts of HIV are present, and intercourse during that phase makes transmission much more likely: infectivity is very high during these short periods, so overall measurements of transmissibility are deceiving.

The first suggestion is absurd, since such behavior would be so visibly evident that it could not be overlooked; yet it is not observed.

The second suggestion has been undermined by a careful re-analysis of the single study on which it had been based: the “excess hazard-months attributable to the acute phase of infection” is about 5.3, not the previously estimated 31-to-141 (Bellan et al., “Reassessment of HIV-1 acute phase infectivity: accounting for heterogeneity and study design with simulated cohorts”, PLoS Medicine, 12(3):  e1001801).

HIV/AIDS research is chasing red herrings, phantoms, in a decades-long wild-goose change that has been enormously expensive in lives and in dollars. But the interests vested in this state of affairs — drug-company profits, research careers, administrative careers, honors and awards — are so widespread and powerful that the actual evidence is given little or no chance of speaking for itself. Try to imagine what it would take for Anthony Fauci to shed cognitive dissonance and admit that he has been so disastrously wrong.

 

Posted in clinical trials, experts, HIV absurdities, HIV and race, HIV does not cause AIDS, HIV tests, HIV transmission, HIV varies with age, HIV/AIDS numbers, Legal aspects, M/F ratios | Tagged: , | 16 Comments »

HIV and Intestinal Dysbiosis: Probiotics are good for HIV+ people

Posted by Henry Bauer on 2016/06/26

I thank Marco Ruggiero for alerting us to these important articles, which report that probiotics can increase CD4 counts and improve health in general:

Irvine et al. (including Gregor Reid), “Probiotic Yogurt Consumption is Associated With
an Increase of CD4 Count Among People Living With HIV/AIDS”, Journal of Clinical Gastroenterology, 44 (2010) e201–e205 (ProbioticCD4increase)

Gregor Reid, “The potential role for probiotic yogurt for people living with HIV/AIDS”, Gut Microbes, 1 (2010) 411-414 (ProbioticReidGutMicrobes)

Ruben Hummelen et al. (including Gregor Reid), “Effect of 25 weeks probiotic supplementation on immune function of HIV patients”, Gut Microbes 2: (2011) 80-85 (25weeks-probiotics)

Posted in Alternative AIDS treatments, antiretroviral drugs, clinical trials | Tagged: , , | 6 Comments »

Gay genes and HIV

Posted by Henry Bauer on 2015/10/06

Some 20 years ago, Dean Hamer reported an association between certain DNA markers and being gay [1]. The report was met with considerable skepticism. Now a new study [2] has reached much the same conclusion as Hamer. This may be relevant to the apparently greater frequency of “HIV-positive” among gay men.

Overall data are clear, that “HIV-positive” does not behave like an infectious condition [3]. More specifically, if “HIV-positive” is ever transmitted sexually then it is with essentially negligible probability, according to the Centers for Disease Control & Prevention:

Heterosexual vaginal transmission is estimated as less than 1 per 1000, but receptive anal intercourse is estimated at 1.4%. This is still less by a large factor than the transmissibility of known venereal diseases like syphilis and gonorrhea. Where does the estimate originate?

It cannot be based on observations in prisons since several such studies reported much lower rates there (p. 47 in [3]). Rather, the estimate likely comes from data on “HIV-positive” among gay men who frequently practice receptive intercourse. In other words, there is a correlation between being gay, receptive anal practices, and testing “HIV-positive”. In prisons, there is a significant amount of anal intercourse by men who are not gay, yet this apparently does not correlate with becoming “HIV-positive”. Evidently it is being gay, more than anal intercourse, that correlates with being “HIV-positive”.

If there is a genetic pre-disposition to being gay, as the Hamer and Sanders studies indicate, then perhaps there is also a genetic pre-disposition among gay men to testing “HIV-positive”.

That some genetic characteristics do predispose to testing “HIV-positive” is demonstrated by racial differences. Men of sub-Saharan ancestry test “HIV-positive” at rates about 7 or 8 times greater than with Caucasian men and about 10 times greater than with Asian men. There are also racial differences in the sensitivity of “HIV” tests to the p24 protein which is one of the “HIV” markers (section 3.4 in The Case against HIV).

I’m not suggesting, of course, that genes could be the sole reason why gay men are more frequently “HIV-positive” than others. Genetic pre-dispositions are probabilistic. Not all gay men test “HIV-positive”. In the earliest days of AIDS, only a small proportion of gay men became ill. Many gay men are both “HIV-positive” and healthy and never contract “AIDS”-type diseases.
Moreover, “HIV-positive” reflects any number of possible conditions, most of which are experienced equally by gay men and everyone else (section 3.2.2 in The Case against HIV).

Similarly, the Hamer and Sanders studies do not suggest that genetics determines sexual orientation, merely that it can bring a heightened tendency; it is explicitly a small effect, to the degree that genetic studies on infants or embryos could not have any useful predictive value [2]. It is widely agreed that behavioral characteristics in general arise from some combination of hereditary and environmental factors. Moreover, it remains to compare the frequent correlation of certain genetic factors with being gay to the overall frequency of those particular factors among all men, which would indicate how strongly those factors may predispose toward a preferred sexual orientation.

So explanations for the greater incidence of “HIV-positives” among gay men are obviously and necessarily partial and multiple. I believe that some proportion of “HIV-positives” among gay men, correlated with also becoming ill, can be explained by the intestinal dysbiosis theory. Here I am suggesting that one possible and additional reason why some gay men are “HIV-positive” may be a genetic pre-disposition, particularly when “HIV-positive” does not correlate with a high probability of illness. Since the markers identified by Hamer and Sanders are not exclusive to gay men, a linkage between those markers and testing “HIV-positive” could also explain some of the incidence of “HIV-positive” among men who are not gay.
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[1] Dean H. Hamer et al., “A linkage between DNA markers on the X chromosome and male sexual orientation,” Science 261 (1993) 321-7
[2] A. R. Sanders et al., “Genome-wide scan demonstrates significant linkage for male sexual orientation”, Psychological Medicine 45 (2015) 1379-88
[3] Henry H. Bauer, The Origin, Persistence and Failings of HIV/AIDS Theory, McFarland 2007

 

Posted in clinical trials, HIV and race, HIV risk groups, HIV tests, HIV transmission, HIV/AIDS numbers, sexual transmission | Tagged: , | Leave a Comment »

Manslaughter by PreEposure Prophylaxis

Posted by Henry Bauer on 2014/07/13

The HIV/AIDS Establishment — Big Pharma, NIAID, etc. etc. — is assiduously promulgating the idea that healthy individuals who engage in sex should imbibe highly toxic substances so that they will be less likely to become “HIV-positive”.

This illustrates how true believers and those with vested interests are able to bias clinical trials to deliver desired results even when much earlier data already established that the desired results cannot have been obtained honestly:  for example, several trials of tenofovir to prevent “HIV infection” managed to report that serious adverse events from tenofovir were no more common than from placebo, even as it has long been established that tenofovir causes kidney failure and other harm.

Since this illustrates general flaws in medicine and science, I posted the full analysis on my scimedskeptic blog rather than here; see When prophecy fails.

Posted in antiretroviral drugs, clinical trials, experts, HIV absurdities, HIV risk groups, HIV transmission, sexual transmission, uncritical media | Tagged: , , , | 5 Comments »