Quality of life when diagnosed HIV+ or AIDS
Posted by Henry Bauer on 2017/05/20
An obscure publication from Universidad Juan Agustín Maza (in Argentina) came to my attention via Research Gate:
“Iniciativas para mejorar la calidad de vida de personas con VIH positivo y SIDA: Revisión del Diagnóstico, el Pronóstico y la Terapéutica a la luz de la Ciencia y de la Ética” by M. E. Molina, J. Abou Medelej, S. Perez Daffunchio, D. E. Crisafulli & J. Álvarez.
[Initiatives to improve the quality of life of HIV-positive and AIDS-diagnosed patients: A review of diagnosis, prognosis, and therapy from viewpoints of science and ethics]
The full article is in Spanish with an Abstract in English:
“The first cases of AIDS occurred in 1981. There are not fully appropriate therapeutic interventions for treating this medical condition yet. People who are diagnosed with positive HIV or AIDS suffer a poor quality of life and receive medication that produces severe adverse reactions. The purposes of this investigation are: * To review the existent reports on the etiology, diagnosis, prognosis and treatment of HIV. * To bring the affected people updated information for healthcare and improvement of their quality of life. We have analyzed a significant number of papers published in several countries on these topics, and we have found the following inconsistencies: * HIV risk behaviors: According to the CDC in the United States, the Estimated Per-Act Probability of Acquiring HIV from an Infected Source, by Exposure Act (heterosexual) is about one in one thousand for woman, and about one on two thousands for man. Nevertheless, an investigation conducted through the University of San Francisco, California, on 442 discordant heterosexual couples no seroconversion was observed throughout the ten years the research lasted. (1985-1995). * Diagnostics methods: In Argentina, we employ the ELISA screening method, posteriorly confirmed by a western blot test, but in the United Stated this last is discouraged since 2014. * Medication: The drugs that are used to treat HIV are DNA chain terminators which interfere with the normal functioning and replication of normal cells. As a result, damage in the immune system and the mitochondrial DNA are reported. We wonder what should we inform the patients and people in general about all these. We require the experts´ opinion on the ethical management aspects. Due that the diagnostic tests employed may result in false positives, and the fact that the medication is highly toxic, we recommend that patients with HIV positive diagnosis re-test their condition at least once a year”.
This all seems quite sound, but after citing false positives, no sexual transmission, and the toxicity of ARVs the last sentence is quite a let-down.
The mention of vaccines is also a mixture of sound and doubtful:[Google translation]:
Regarding the possible development of vaccines.
The difficulty in developing vaccines due to HIV mutation has been explained: the high coding error rate produced by the reverse transcriptase enzyme and the recombination of various phenotypes of HIV in the DNA of infected cells (Montagnier L., 2008). However, other retroviruses that respond to the same replication mechanisms do not produce mutations that impede the development of vaccines. Example: Murine Leukemia Virus. Likewise, a purification of up to 20% of HIV has not been reported to date, so doubts remain about the specificity of antibodies used in diagnosis (Leung, Hans Gelderblom Extended Interview min 37.48) , 2011”
Evidently the authors accept HIV/AIDS theory but are puzzled by its internal contradictions.
This entry was posted on 2017/05/20 at 2:56 pm and is filed under antiretroviral drugs, experts, HIV tests, HIV transmission, Legal aspects, sexual transmission, vaccines. Tagged: treatment of HIV/AIDS. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
Eduardo said
It’s a very confusing article indeed.. why the need to retest once a year? Once positive, always positive! Also, when was that 20%purification achieved and where?
Henry Bauer said
Eduardo:
NO. There are many reports of HIV+ becoming HIV-negative. Naturally, since HIV+ dos not mean infected by a retrovirus.
Mario Enrique Molina said
Dear Sirs, I am one of the authors of this paper. Our aim in asking for re-testing is to demonstrate that hiv testing results may be inconsistent. I hope once we have 50% inconsistencies in the hiv positive population the hiv test will be put in doubt, and more research will be elicited.
Thank you for reading and considering our research.
Do not hesitate in contacting me for further comments and suggestions.
Another goal of re-testing will be suggesting hiv positive (now negative) people ceasing the intake of hiv specific drugs. By re-testing I mean Eliza and Western Blot, not PCR nor T-CD4 counting.
Henry, please, would you be so kind as to send me some references to these reports (HIV + becoming HIV -)? Thank you in advance, Mario
Henry Bauer said
Mario:
Thank you for the additional information.
As to spontaneous re-conversion from HIV+ to HIV-, have a look at THE CASE AGAINST HIV where I collected pertinent references. Section 3.3.4.1 is about HIV+ babies becoming negative; 3.3.8.1 is drug addicts reverting to HIV-; 4.4.5 links to 6 items about spontaneous reconversion. One of them mentions pp. 96ff. in my book, The Origin, Persistence and Failings of HIV/AIDS Theory (McFarland 2007) where I argue that the way the rate of “HIV+” in the American population varies with age demonstrates that there must be a great deal of spontaneous reversion.
Mario Enrique Molina said
Dear Henry,
Thank you so much for your kind and prompt answer.
We will be reading this valuable reference, including the concepts, and citing it, in our coming papers.
Sincerely,
Mario
benedetto said
errata corrige
dear dr Mario Enrique Molina,
it would be nice to know how you can possibly distinguish between a false positive from a TRUE one..thanks
Mario Enrique Molina said
Dear Benedetto,
Your question is very interesting.
The right answer would be: we compare the results of a certain new proposed test with a “gold-standard” test -for certain condition-, and we compare them to see whether the “new proposed test” shows coincidence with the results of the “gold standard” repeatedly. In case the gold standard shows “negative” and the new proposed test shows “positive”, this last would be a “false positive”.
Now, in these days we have two problems for doing this with hiv tests:
1) There is no “gold standard”. Actually, the Gold Standard woud be to see the “hiv” virions under electromicrography This is not done anywhere for diagnostic purposes.
2) Currently, a person who is diagnosed positive for hiv is never re-tested, as it is assumed that this condition will not vary lifelong. This is certainly irrational, IMHO. So, I suggest to test and retest people once a year to see if their positive condition varies with time. In case a person had been diagnosed positive once, and many times after this his results show “negative”… What would be the explanation? That this person was falsed diagnosed positive before. At least, there is a possibility for this to be the case.
Thank you again!
Best regards,
Dr. Mario Molina
Mario Enrique Molina said
Dear readers, Universidad Juan Agustín Maza has retracted this paper from the official University Journal website. So I am retracting it from Research Gate, and re-sending it to a new journal. As soon as it is published again I will post the link here. Sincerely, Mario Molina
Mario Enrique Molina González said
Dear readers, we have published this revised article in the American Journal of Immunology.
Please find our paper in the following link:
http://thescipub.com/abstract/10.3844/ofsp.11377
Nancy Domínguez said
Estimado Dr. Mario Enrique Molina: Me interesa tener una comunicación con usted y su equipo, me ha llegado su trabajo y valoro que una en una Universidad de nuestro país se planteen este tipo de cuestiones. Soy médica e investigo este tema desde los inicios y siempre he manifestado mis dudas con respecto a la información “oficial”.Quedo a su entera disposición.
[
363/5000
Dear Dr. Mario Enrique Molina: I am interested in having a communication with you and your team, I have received your work and I value that one in a University of our country should raise this type of issues. I am a doctor and I have been researching this subject since the beginning and I have always expressed my doubts regarding the “official” information. I am at your disposal.]
Nancy Domínguez
El Hoyo, Chubut
Mario Molina said
Hola Nancy! Gusto de conocerte, y de ver que compartimos inquietudes!
wsp 261 6940 654
Cordial abrazo desde Mendoza!
Hi Nancy, pleased to meet you, and to share interests.
Best regards from Mendoza.
Thank you Henry Bauer for the possibilities you open with this initiative!
Nancy Domínguez said
Hola Mario! Pronto nos comunicaremos. Mi wsp es 11 4087 3562 Y extiendo mi agradecimiento a Henry Bauer!!!!
[Hello Mario! We will communicate soon. My wsp is 11 4087 3562 And I extend my thanks to Henry Bauer !!!!]
David Bailey said
I hope this paper is translated into English soon (and published here, if nowhere else), and that retesting of HIV patients becomes an accepted practice!
Henry Bauer said
David Bailey:
Here it is, from American Journal of Immunology:
http://thescipub.com/PDF/ofsp.11377.pdf
Mario said
Dear David Bailey.
It has been published in English:
http://thescipub.com/abstract/10.3844/ofsp.11377
You can access the full text in a link inside.
Thank you for your interest!
Dr. Mario Molina
Mario said
Dear friends,
I have published a second part of our first paper. Please find it here:
https://www.researchgate.net/publication/327802878_Six_Reasons_to_Re-Test_HIV_Positive_Subjects_through_Enhanced_Protocols_under_a_Yearly_Basis_and_to_Communicate_the_Results_to_the_Scientific_Community
Let me know about your thoughts!
Best regards from Argentina!
Mario