Darin BrownIntestinal dysbiosis hypothesis goes mainstream
Posted by Henry Bauer on 2017/05/20
It seems that the idea of recommending probiotics for “HIV+” people has become downright mainstream now. The following links were sent me by Tony Lance; they mention among other things dysbiosis and microbial translocation, which Tony had pointed to in his essay, cited on this blog nearly a decade ago (What really caused aids: slicing through the Gordian Knot).
“Impact of probiotic Saccharomyces boulardii on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled trial” by Judit Villar-García et al.
“Microbes & HIV” by Jeannie Wraight
“STUDY: Probiotic could help prevent disorders in people with HIV” by Jeannie Wraight.
This mentions “A new study reported in the International Journal of Molecular Sciences”, presumably “Probiotics differently affect gut-associated lymphoid tissue indolamine-2,3-dioxygenase mRNA and cerebrospinal fluid neopterin levels in antiretroviral-treated HIV-1 infected patients: A pilot study” by Carolina Scagnolari et al. [Int. J. Mol. Sci. 2016, 17(10), 1639; doi:10.3390/ijms17101639] .
This article was in a special issue of IJMS, “Immuno- and Neuropathogenesis of HIV Disease: Mechanisms, Prevention, Treatment, and Cure” which included another pertinent piece:
“Impact of HIV infection and anti-retroviral therapy on the Immune profile of and microbial translocation in HIV-infected children in Vietnam” by Xiuqiong Bi et al. [Int. J. Mol. Sci. 2016, 17(8), 1245; doi:10.3390/ijms17081245] .
Neither of those sources mentions the probiotic Visbiome, referred to in Wraight’s article. However, the Visbiome website cites “Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitochondrial morphology in ART-treated HIV-1-positive patients” by Gabriella d’Ettorre et al. [Immunity, Inflammation and Disease, 2017; doi: 10.1002/iid3.160] whose Conclusions are worth quoting:
“These findings highlight the potential beneficial effects of probiotic supplementation for the reconstitution of physical and immunological integrity of the mucosal intestinal barrier in ART-treated HIV-1-positive patients”.
This entry was posted on 2017/05/20 at 3:28 pm and is filed under Alternative AIDS treatments, antiretroviral drugs, clinical trials, HIV in children. Tagged: intestinal dysbiosis, microbial translocation, probiotics. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
HIV/AIDS Skepticism 
Leo said
Hi Dr. Bauer,
I’ve read this theory and it does make sense. but what I don’t understand is that why don’t porn actresses who do so much anal develop this Intestinal dysbiosis and start testing positive for HIV?
Also, I keep thinking that the HERV theory presented by Dr. Etienne de Harven makes a lotta sense..
Henry Bauer said
Leo:
Anal intercourse alone cannot inevitably cause “HIV/AIDS” since men have been doing this for millennia whereas “HIV/AIDS” is a new phenomenon.
One ironic possibility is that being hygienic by douching might bring on dysbiosis.
The “fast lifestyle”, excessive exuberance, promiscuous sex and bouts of gonorrhea, syphilis, etc., “cured” via antibiotics almost certainly contributed; and “recreational” drugs — nitrite poppers were almost certainly the cause of “AIDS Kaposi’s”. Kramer’s novel FAGGOTS and a documentary film “When ocean meets sky” describe the very unhealthy practices of some small proportion of gay men following “Gay Liberation”.
It’s too often forgotten that “HIV” and “AIDS” did not and do not affect all gay men.
Lukas said
Hi dr Bauer, It seems that chinese herbs have also documented positive activity on HIV.They could be used in combination with probiotics to amplify their effects.Montaigner,recently has said he believes herbs can treat HIV.I suggest to read with attention the following recent abstract of a paper that proves that benefits of herbs are consistent: http://online.liebertpub.com/doi/10.1089/aid.2016.0288
Henry Bauer said
Lukas:
One also needs a control group of untreated. Recall that homeopathy got a foothold when homeopathically treated, i. e. physiologically untreated cholera patients survived better than those treated by then-conventional methods like bleeding, similarly toxic as ARVs are
Lukas said
This very recent paper also demonstrates documented antiviral property of a plant extract,It is written with the collaboration of the department of immunology of University of Illinois,give a look: http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.7b00004
Samuel Mwaniki said
Great read right there!