Posted by Henry Bauer on 2011/09/29
AIDS Rethinking was again disseminated to mainstream researchers, this time at the 65th Annual Congress of the Italian Society for Anatomy and Histology in Padua, 27-29 September 2011.
An extensive poster presentation (authors: Ruggiero, Pacini, Punzi, Morucci, Gulisano, Köhnlein, Bauer) discussed “The Clinical Significance of Immune-System Laboratory Tests”. The poster makes the following salient points:
→ Scientists accept conclusions of experts in fields outside their own specialties. The resulting mainstream “consensus” can remain unchanged for a long time even after the experts have modified or discarded their earlier conclusions.
→ That is so with HIV/AIDS, where evidence has accumulated that the original hypothesis was wrong:
♦ Kaposi’s sarcoma is not caused by HIV.
♦ Many clinical AIDS cases were found to be HIV-negative
(and renamed — entirely ad hoc — “idiopathic CD4-T-cell lymphopenia”).
♦ Anti-retroviral drugs often cause clinical deterioration instead of
helping patients recover (“immune restoration syndrome”).
Patients on Highly Active Anti-Retroviral Therapy (HAART)
experience more adverse non-AIDS events than AIDS events.
♦ “HIV” tests are anything but specific; false-positives arise from a host of conditions
that are not necessarily health-threatening.
♦ CD4 counts are not a good biomarker of clinical condition, nor a criterion of illness,
still less a reason for instituting HAART.
→ Treating manifest illnesses has a better record of good patient outcomes than does antiretroviral treatment.
→ CD4 counts can be increased quickly and safely by means of probiotic dietary supplements.
[The poster is available for download but takes appreciable time because of its size, ~32 MB as jpg and ~50 MB as pdf]
Expanding on the question of CD4 counts and probiotics, Pacini, Punzi, Morucci, Ruggiero, & Cheney presented a study entitled “Macrophages of the Mucosa-Associated Lymphoid Tissue (MALT) as key elements of the immune response to vitamin D binding protein-macrophage activating factor (GcMAF)”:
→ Probiotic yogurt has been shown to increase CD4 counts in people living with HIV/AIDS.
→ The results were not replicated with encapsulated probiotics, suggesting the need for an additional factor. GcMAF has been found to act as such a factor.
→ Increased CD4 counts under such a regimen have been demonstrated recently in several control subjects, in an HIV-positive patient, and in two individuals affected by chronic fatigue syndrome.
→ Natural Killer (NK) cell counts increased as well as CD4 counts and CD4/CD8 ratio. The significance is that NK cells influence the quality of immune responses, are associated with the clinical prognosis for “HIV-positive” patients, and play a major role in HIV elite controllers.
→ There were also favorable changes in hematological parameters indicative of bone-marrow function, and there was significant improvement in general health.
The substance of these posters is available in printed form in the Italian Journal of Anatomy & Embryology, 116 #1 (2011) respectively pages 157 and 136.
Posted in Alternative AIDS treatments, HIV risk groups, HIV skepticism | Tagged: GcMAF, probiotics increase CD4 counts | 8 Comments »
Posted by Henry Bauer on 2011/04/28
A key aspect of intestinal dysbiosis theory has been confirmed: Re-establishment of healthy gut microflora can lead to an apparent defeat of “HIV infection” — an increased CD4 count.
AIDS originally manifested as 3 diseases: candidiasis (thrush; yeast infections), Pneumocystis carinii pneumonia (PCP), and Kaposi’s sarcoma (KS).
Given that many KS patients are HIV-negative, it has been acknowledged for many years now, even by HIV/AIDS cultist, that Kaposi’s sarcoma is not caused by HIV. A sufficient explanation for the prevalence of KS in the early 1980s, and its increasing rarity since, is that it was caused by excessive use of nitrite poppers (see Death Rush by John Lauritsen & Hank Wilson).
It had not been recognized at first that PCP, like candidiasis, is a fungal infection (and it has been renamed Pneumocystis jiroveci, but I shall continue to use “PCP” since that has been so long and widely used and recognized).
An adequate explanation for the outbreak of AIDS in the early 1980s is the “fast-lane” lifestyle of a small proportion of gay men as part of the irrational exuberance that followed the apparent “gay liberation” of the 1970s: these men were sleeping little and partying much, sharing and spreading the common sexually transmitted diseases, treating those frequent infections with lots of antibiotics, even consuming antibiotics promiscuously as prophylactics (see for example the 2003 TV documentary, When Ocean Meets Sky). Dr. Josef Sonnabend, whose practice in New York included many gay men, predicted even in the 1970s that this lifestyle would lead to a breakdown of health. It did.
But why specifically yeast and PCP? Why specifically fungal diseases?
In conjunction with the hypothesis of intestinal dysbiosis, Tony Lance pointed out that certain aspects of and practices associated with the fast-lane gay lifestyle seem as if designed to damage the intestinal microflora that constitute the first line of defense established by the immune system, a defense that acts particularly to hold in check fungal organisms that are ubiquitous.
The notion that HIV causes AIDS is disproved by many types of evidence. But that still leaves a conundrum: Why do gay men even nowadays so often test “HIV-positive”? Even gay men who remain in good health for decades without antiretroviral treatment?
Lance suggested that the damage to gut microflora would allow translocation from the gut to the blood of a variety of substances that might cause reactions that could manifest as responding positive on “HIV” tests. That suggestion has been confirmed in recent years as a significant number of mainstream articles have acknowledged an important role for the gut microflora as part of the immune system, and that damage to this mucosal immune-system allows translocation and “immune activation” — the latest hand-waving term that substitutes for a specific mechanism by which “HIV” is supposed to cause damage.
CD4 counts and viral load are the standard measures for inferring the course that “HIV infection” is taking: higher CD4 or lower viral load means the “infection” is being successfully controlled. Now it has been found that probiotic treatment, helping a healthy gut microflora re-establish itself, leads to higher CD4 counts and to a decrease in immune activation — to controlling “HIV infection”, in other words, without recourse to antiretroviral drugs:
Clerici et al., “Nutritional intervention with NR100157 restores gut microbiota in HIV-1-infected adults not on HAART and reduces systemic immune activation”, 18th Conference on Retroviruses and Opportunistic Infections (Boston, MA, February 27 — March 2, 2011):
“Background: A compromised gastrointestinal tract can contribute via microbial translocation to the persistent chronic immune activation observed in HIV-infected individuals. Previously, the nutritional concept NR100157 containing prebiotic oligosaccharides was shown to reduce CD4+ T cell decline in HIV-1-infected adults, in the double-blind placebo controlled BITE trial, after 52 weeks intervention. This was associated with decreased immune activation in a subpopulation. . . .
Conclusions: This study shows that nutritional intervention with NR100157 beneficially affects the gut microbiota composition in HIV-1-infected adults. Microbiota changes correlated with CD4+CD25+ T cell changes in a subgroup analysis, implying positive effects of NR100157 on intestinal homeostasis and systemic immune activation.”
Posted in Alternative AIDS treatments, clinical trials | Tagged: intestinal dysbiosis theory confirmed, probiotics increase CD4 counts | 13 Comments »