HIV/AIDS Skepticism

Pointing to evidence that HIV is not the necessary and sufficient cause of AIDS

Posts Tagged ‘microbial translocation’

Intestinal dysbiosis hypothesis goes mainstream

Posted by Henry Bauer on 2017/05/20

It seems that the idea of recommending probiotics for “HIV+” people has become downright mainstream now. The following links were sent me by Tony Lance; they mention among other things dysbiosis and microbial translocation, which Tony had pointed to in his essay, cited on this blog nearly a decade ago (What really caused aids: slicing through the Gordian Knot).

“Impact of probiotic Saccharomyces boulardii on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled trial” by Judit Villar-García et al.

“Microbes & HIV” by Jeannie Wraight

“STUDY: Probiotic could help prevent disorders in people with HIV” by Jeannie Wraight.
This mentions “A new study reported in the International Journal of Molecular Sciences”, presumably “Probiotics differently affect gut-associated lymphoid tissue indolamine-2,3-dioxygenase mRNA and cerebrospinal fluid neopterin levels in antiretroviral-treated HIV-1 infected patients: A pilot study” by Carolina Scagnolari et al. [Int. J. Mol. Sci. 2016, 17(10), 1639; doi:10.3390/ijms17101639] .
This article was in a special issue of IJMS, “Immuno- and Neuropathogenesis of HIV Disease: Mechanisms, Prevention, Treatment, and Cure” which included another pertinent piece:

“Impact of HIV infection and anti-retroviral therapy on the Immune profile of and microbial translocation in HIV-infected children in Vietnam” by Xiuqiong Bi et al. [Int. J. Mol. Sci. 2016, 17(8), 1245; doi:10.3390/ijms17081245] .

Neither of those sources mentions the probiotic Visbiome, referred to in Wraight’s article. However, the Visbiome website  cites “Probiotic supplementation promotes a reduction in T-cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and mitochondrial morphology in ART-treated HIV-1-positive patients” by Gabriella d’Ettorre et al. [Immunity, Inflammation and Disease, 2017; doi: 10.1002/iid3.160]  whose Conclusions are worth quoting:
“These findings highlight the potential beneficial effects of probiotic supplementation for the reconstitution of physical and immunological integrity of the mucosal intestinal barrier in ART-treated HIV-1-positive patients”.

 

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